Tretinoin is a (synthetic) derivative of Vitamin A, first discovered in the 1960s by the dermatologist and researcher, Dr. Albert Kligman. 

After studying the effects of Tretinoin on the skin, Dr. Kligman identified Tretinoin as a promising compound for treating various skin conditions such as acne.

By targeting its underlying causes, Tretinoin revolutionised the treatment of acne. It works by increasing skin cell turnover thus preventing the formation of comedones (clogged pores). The promotion of new skin cell turnover also helps reduce the appearance of hyperpigmentation, fine lines and wrinkles and even stubborn keratosis pilaris. 

Tretinoin has been extensively studied over the past 6 decades and its mechanisms of action and therapeutic benefits have been well-documented.

  1. Start with clean skin: Wash your face gently with a mild cleanser and pat it dry before applying tretinoin. Ensure your skin is completely dry before application to minimise irritation.
  2. Apply a pea-sized amount: Take a pea-sized amount of tretinoin and dot it on your forehead, cheeks, chin, and other affected areas of the skin. Avoid the sensitive areas around the eyes, lips, and nostrils.
  3. Spread evenly: Using clean fingertips, spread the tretinoin evenly over the entire area. Be gentle and avoid excessive rubbing or stretching of the skin.
  4. Gradual introduction: If you are new to tretinoin or have sensitive skin, we recommend starting with a lower concentration and frequency of use.
  5. Timing and frequency: Tretinoin should be applied at night, as it can increase sensitivity to sunlight. Initially, you should use it a few times a week, gradually increasing to every other night.
  6. Moisturise: Make sure to apply a hydrating moisturiser to help soothe the skin. Look for non-comedogenic or oil-free moisturizers. Consider the sandwich method. 
  7. Sun protection: During the day, it is crucial to protect your skin from the sun as tretinoin can increase sun sensitivity. Apply a broad-spectrum sunscreen with SPF 30 or higher, and consider wearing protective clothing and seeking shade when exposed to sunlight.
  8. Be patient: It takes time for tretinoin to show visible improvements. Results may be seen within a few weeks to several months of consistent use. Be patient and remember that skincare is a long-term effort. 

Tretinoin remains a clinically proven and widely used treatment option in dermatology. It is regarded as one of the most effective topical agents for managing acne and improving the overall appearance and health of the skin.

Tretinoin, when used correctly and under medical supervision, can be beneficial for severe acne. It helps unclog pores, reduce inflammation, and promote skin cell turnover, which can lead to an improvement in acne lesions over time. However, it may take several weeks to see noticeable results, and some individuals may experience an initial worsening of acne (often referred to as ‘purging’) before seeing improvement.

If you have never used Tretinoin before, we recommend starting with the lowest percentage which is 0.025%.

This is called the “purging stage” which can happen and is totally normal. You may experience an increase in the number of pimples, whiteheads, blackheads or even small bumps on the skin. This happens because Tretinoin increases skin cell turnover which can bring underlying acne lesions to the surface more rapidly. This can sometimes be part of the journey to beautiful, healthy skin.

You should usually see a difference within the first 4 months however it’s important to note that the effectiveness of tretinoin may vary depending on factors such as the individual’s skin type, the specific condition being treated, the concentration and formulation of tretinoin used, and proper adherence to treatment guidelines.

We usually recommend Tretinoin gel for customers with oilier skin and Tretinoin cream for customers with dryer/ more mature skin.

Using too much tretinoin or applying it more frequently than prescribed can cause excessive dryness, redness, peeling, and sensitivity. It is important to follow your healthcare professional’s instructions and use tretinoin as directed to minimise the risk of side effects. If you experience severe or persistent irritation, you should consult your healthcare provider.

You can buy Tretinoin in the UK from TretinoinShop here

Subscribe for exclusive discounts & offers.

Be the first to know about new collections and exclusive offers.

    Shopping cart


    No products in the cart.

    Continue Shopping